Actor, writer, director, and producer Clark Middleton has died, his wife Elissa confirmed in social media posts on Monday. Middleton, known for various roles in Twin Peaks, Law & Order, Kill Bill: Vol. 2, and The Blacklist. He was 63.

Middleton died on Sunday from West Nile Virus in his Los Angeles home, his wife Elissa Middleton said in a statement. The virus can be found in mosquitos and has no cure or vaccine.

“With heavy hearts, we announce the passing of a life eminently worthy of celebration: Clark Tinsley Middleton, 63 – beloved actor, writer, director, teacher, hero, husband, beacon, friend,” she wrote, according to Variety. “Clark transitioned on October 4th as a result of West Nile Virus, for which there is no known cure. Clark was a beautiful soul who spent a lifetime defying limits and advocating for people with disabilities.”

“Thank you for your love and support for My Mister,” Elissa Middleton said in a post on Twitter. “I cannot count the number of times he said ‘Give the world your best and the best will come back to you,’ quoting his father Mel. And he meant it! He is in the light, happy and free, and sends love.”

Born in 1957, Middleton was diagnosed with Rheumatoid Arthritis when he was just four years old. The actor began his entertainment career in 1983 as part of the congregation in the “Miss Lonelyhearts” episode of American Playhouse.

Middleton was known for his performances in “The Blacklist,’ “Twin Peaks” and “Kill Bill: Vol. 2.” His decades in the film industry included work with directors such as Henry Bean, Ang Lee, Richard Linklater, Frank Miller, Robert Rodriguez, and Quentin Tarantino.

“I am so happy thinking of his newfound freedoms and I know his transition will be graced by the beautiful souls he loved who preceded him,” Elissa Middleton added in a Facebook post. “We are so happy you loved him too and hope you will join us celebrating his remarkable life.”

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