Proton pump inhibitor (PPI) are medications whose main action is to mitigate and reduce the production of stomach acid. Within the class of medications, there is no clear indication that one agent works better than another.

A view of American Research

A study published in American Journal of Gastroenterology shows the positive relationship between proton pump inhibitor and COVID-19. The study found that PPI use, especially twice-daily dosing, is linked with an increased bulge for reporting a positive COVID-19 test, even after computing for a wide range of lifestyle, and clinical variables.

Directions to use PPI

Research findings continue to underscore that PPIs should only be used when they are clinically indicated at the lowest efficient dose. It is necessary to consult with a health provider before using of proton pump inhibitor. We should avoid suggesting medications by our self.

Results of Research

A population based research was conducted through online surveys to find out the reality of the increased risk of COVID-19 attack for PPI users. Researchers used most variable logistic regression to report on a positive COVID-19 test to adjust confusing factors.

Research showed that 3,267 patients who tested positive were symptomatic and 647 patients showed the symptoms of abdominal pain, diarrhea, and nausea. Results from regression analysis exhibited that patients who took lower-dose PPIs had a lower chance of reporting GI COVID-19 symptoms compared with patients who did not use PPIs.


This study does not mean that people on PPIs should stop their medicine. As always, the decision about whether, when, and how to adjust PPI dosing should be based on a mindful valuation of the risk and benefit ratio for respective patients. Medication’s lowest effective dose should be used on clinical indications. In this regard, H2RAs may also be used as an alternative treatment for acid-related conditions.

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Hi! I am Madiha Anwar. Reading books and pursue skills is my passion since my childhood. Always dream to serve homo-sapiens along with this knowledge. Being a medical student I would love to write on health suggestions. I desire that articles bring a healthy change in your life. Stay tuned & stay healthy!

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