What caused migraine - Insight Trending

A new study suggest that the cause of the migraine in human are caused by a genetic variant that had helped in early human to adapt to cold weather. 

Migraine is the 3rd most prevalent illness in the world.
Migraine is a neurological disease with extremely incapacitating neurological symptoms.

The people living in European descent suffer most from migraine, which is also the population with the highest frequency of the cold-adaptive variant, the study said.

The study, published in the journal PLOS Genetics, suggest that the ability to adapt to cold weather
in early human population may have lead to some variation in migraine that exists among human these days. 

In the last 50,000 years, some humans left the warm climate of Africa to colonize colder locales in Asia, Europe, and other parts of the world. "This colonization could have been accompanied by genetic adaptations that helped early humans respond to cold temperatures," said Aida Andres, also from Max Planck Institute for Evolutionary Anthropology.

To find evidence of this adaptation, the researchers took a closer look at TRPM8, a gene that codes for the only known receptor that enables a person to detect and respond to cool and cold temperatures. They discovered that a genetic variant upstream from the gene, which may regulate it, became increasingly common in populations living in higher latitudes during the last 25,000 years. Currently, the percentage of people in a population that carry the variant increases at higher latitudes and with colder climates,the study said. Interestingly, scientists had already identified this variant as being strongly associated with migraine headaches.

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